BP

Publications:

Patents:

1.	WO 02/094796 A2 Title: Benzo[g]quinoxaline derivatives as effective compounds against infectious diseases Inventors: Pató János, Kéri, György; Őrfi, László; Wáczek, Frigyers; Horváth, Zoltán; Bánhegyi, Péter; Szabadkai, István; Marosfalvi, Jenő; Hegymegi-Barakonyi, Bálint; Székelyhidi, Zsolt; Greff, Zoltán; Choidas, Axel; Bacher, Gerald; Daub, Henrik; Obert, Sabina; Kurtenbach, Alexander; Habenberger, Peter
2.	US 2004/0171603A1 Title: Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor Inventors: Janos Pato, Gyorgy Keri, Laszlo Orfi, Frigyes Waczek, Zolta Horvath, Peter Banhegyi, Istvan Szabadkai, Jeno Marosfalvi, Balint Hegymegi-Barakonyi, Zsolt Szekelyhidi, Zoltan Greff, Axel Choidas, Gerald Bacher, Andrea Missio, Anil Koul
3.	WO 2005023818 A2, US 60577043, EP 040128142 Title: Heterobicyclic compounds as pharmaceutically active agents Inventors: Koul, Anil; Klebl, Bert; Mueller, Gerhard; Missio, Andrea; Schwab, Wilfried; Hafenbradl, Doris; Neumann, Lars; Sommer, Marc-Nicola; Mueller, Stefan; Hoppe, Edmund; Freisleben, Achim; Backes, Alexander; Hartung, Christian; Felber, Beatrice; Zech, Birgit; Engkvist, Ola; Keri, Gyoergy; Oerfi, Laszlo; Banhegyi, Peter; Greff, Zoltan; Horvath, Zoltan; Varga, Zoltan; Marko, Peter; Pato, Janos; Szabadkai, Istvan; Szekelyhidi, Zsolt; Waczek, Frigyes
4.	WO 03084947 A1, EP 1492783 Title: 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and methods for medical intervention against mycobacterial infections Inventors: Missio Andrea; Bacher Gerald; Koul Anil; Choidas Axel; Banhegyi Peter; Greff Zoltan; Keri Gyoergy; Marko Peter; Oerfi Laszlo; Waczek Frigyes; Pato Janos
5.	US 60502606, US 60551341, EP 030206163, EP 040048910 Title: 4,7-Dihydro-5H-thieno[2,3c]pyran derivatives and their analogues as effective compounds against infectious diseases

Posters:

1.	Antiproliferative efficacy of a tyrosine kinase inhibitor focused library 45^th Annual Meeting of the Hungarian Society of Gastroenterology, 3-7 Juni, 2003 Balatonaliga, Hungary Szabó E.Z., Schwab R., Bökönyi Gy., Hollósy F., Wáczek F., Bánhegyi P., Hegymegi-Barakonyi B., Németh B., Várkondi E., Schäfer E., Radinovic S., Gyökeres T., Hamvas J., Idei M. Őrfi L., Kéri Gy. and Pap Á.
2.	5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine Derivatives as Potent and Selective, ATP Side Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase 8^th Solid Phase Synthesis & Combinatorial Libraries Drug Discovery, Development & Delivery Antibody & Vaccine Strategies, 2^nd-6^th Sept 2003, Imperial College, London, England, UK Péter Bánhegyi*, László Őrfi, Frigyes Wáczek, Zsolt Székelyhidi, Gyöngyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Richárd Schwáb and György Kéri
3.	Synthesis of thiophene and α-terthiophene derivatives with antiproliferative activity 8^th Solid Phase Synthesis & Combinatorial Libraries Drug Discovery, Development & Delivery Antibody & Vaccine Strategies, 2^nd-6^th Sept 2003, Imperial College, London, England, UK Zsolt Székelyhidi*, János Pató, László Őrfi, Frigyes Wáczek, Péter Bánhegyi, Gyöngyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Ákos Pap, Richárd Schwáb and György Kéri
4.	Antiproliferative Efficacy of a Focused Library of Tyrosine-Kinase Inhibitors 35th European Pancreatic Club (EPC) Meeting Liverpool, UK, June 18-22, 2003 E.Z. Szabó, R. Schwab, G. Bökönyi, F. Hollósy, F. Wáczek, P. Bánhegyi, B. Hegymegi-Barakonyi, B. Németh, E. Várkondi, E. Schafer, S. Radinovic, T. Gyökeres, J. Hamvas, L. Őrfi, M. Idei, G. Kéri. and Á. Pap
5.	5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine derivatives as potent and selective, ATP side directed inhibitors of the EGF-receptor protein tyrosine kinase Semmelweis Egyetem PhD Tudományos Napok 2004 Péter Bánhegyi, Frigyes Wáczek, László Őrfi, Bálint Hegymegi-Barakonyi, Zsolt Székelyhidi, Györgyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Ákos Pap, Richárd Schwáb, György Kéri
6.	Synthesis of Thiophene and α-Terthiophene derivatives with Antiproliferative Activity Semmelweis Egyetem PhD Tudományos Napok 2004 Zsolt Székelyhidi, János Pató, László Őrfi, Bálint Hegymegi-Barakonyi, Péter Bánhegyi, Györgyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Ákos Pap, Richárd Schwáb and György Kéri
7.	Synthesis of Benzo[4,5]thieno[2,3-d]pyrimidin-4-yl-amine derivatives with EGF-Receptor Protein Tyrosine Kinase inhibitor activity XVIII`th International Symposium on Medicinal Chemistry Copenhagen, Denmark&Malmö, Sweden August 15-19, 2004 Péter Bánhegyi, Frigyes Wáczek, László Őrfi, Bálint Hegymegi-Barakonyi, Zsolt Székelyhidi, Györgyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Ákos Pap, Richárd Schwáb, György Kéri
8.	Synthesis and characterization of new heterocyclic compounds as potential bioavailable antitumor agents XVIII`th International Symposium on Medicinal Chemistry Copenhagen, Denmark&Malmö, Sweden August 15-19, 2004 Bálint Hegymegi-Barakonyi, Edit Szabó, Zsolt Székelyhidi, Péter Bánhegyi, János Pató, Edit Várkondi, Frigyes Wáczek, György Kéri and László Őrfi
9.	Synthesis of antitumour compounds based on thiophene and α-terthiophene scaffold XVIII`th International Symposium on Medicinal Chemistry Copenhagen, Denmark&Malmö, Sweden August 15-19, 2004 Zsolt Székelyhidi, János Pató, László Őrfi, Bálint Hegymegi-Barakonyi, Péter Bánhegyi, Györgyi Bökönyi, Edit Z. Szabó, Edit Várkondi, Richárd Schwáb and György Kéri
10.	Screening Tyrosine Kinase Inhibitors Targeting Pancreatic Cancer: Validation of Assays on Platelet Derived Growth Factor Receptor 46^th Annual Meeting of the Hungarian Society of Gastroenterology, 3-7 Juni, 2004 Balatonaliga, Hungary Gy. Bökönyi, E. Várkondi, E. Schäfer, P. Bánhegyi, Zs. Székelyhidi, T. Gyökeres, J. Hamvas, Tejeda M, L. Őrfi, Gy. Kéri, R. Schwab, Á. Pap
11.	Testing and characterising focused tyrosine kinase inhibitory libraries 18^th American Peptide Symposium, Boston, USA, 19-23 Juni 2003. Gy. Bökönyi, E. Schäfer, E. Várkondi, E. Z. Szabo, F. Wáczek, Zs. Székelyhidi, P. G. Bánhegyi, Gy. Mészáros, D. Erős, L. Őrfi, Á. Papp, R. Schwáb, Gy. Kéri
12.	Robust synthesis of ortho-cyano-heteroarylamines, building blocks of ATP like kinase inhibitors 2^nd International Meeting on Medicinal and Pharmaceutical Chemistry, Antalya, Turkey, 10-14 October 2004 Frigyes Wáczek, Jenő Marosfalvi, Zoltán Varga, Zsolt Székelyhidi, Péter Bánhegyi, Gyula Bencze, Richárd Schwáb, Edit Szabó, Beatrix Németh, György Kéri, László Őrfi
13.	A general method for the screening of peptidomimetic libraries by elisa based tyrosine kinase assay 3rd International and 28th European Peptide Symposium, Prague, Czech Republik, September 5-10, 2004 Gy. Bökönyi, E. Schäfer, E. Várkondi, E. Z. Szabo, F. Wáczek, P. Bánhegyi, Zs. Székelyhidi, B. Hegymegi-Barakonyi, L. Őrfi, T. Vántus, R. E. Schwáb, Gy. Kéri

Lectures:

CDK1 inhibítor hatású spiro(1-benzazepin-4,1`-ciklohexán) származékok előállítása

Magyar Tudományos Akadémia Peptidkémiai Munkabizottság ülése, 2002, május 29-31, Balatonszemes

Bánhegyi Péter*, Őrfi László, Kéri György

Signal Transduction Therapy with Antitumor peptides and peptidomimetics

8^th Solid Phase Synthesis & Combinatorial Libraries Drug Discovery, Development & Delivery Antibody & Vaccine Strategies, 2^nd-6^th Sept 2003, Imperial College, London, England, UK

György Kéri, János Pató, Zsolt Székelyhidi, Péter Bánhegyi, István Teplán, Béla Szende, László Őrfi

Inhibitors of a mycobacterial protein kinase target and their conversion into novel drug candidates for Mycobacterium tuberculosis infected patients

30^th FEBS Congress - 9^th IUBMB Conference, 2^nd-7^th July, 2005, Budapest, Hungary

L. Õrfi, A. Koul, D. Hafenbradl, B. Klebl, E. Hoppe, A. Missio, G. Müller, A. Ullrich, J. Pató, F. Wáczek, P. Markó, P. Bánhegyi, Z. Greff and G. Kéri

Articles:

1.	Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives Bioorganic & Medicinal Chemistry Letters, 2005, 15, 3241-3246 Zsolt Székelyhidi, János Pató, Frigyes Wáczek, Péter Bánhegyi, Bálint Hegymegi-Barakonyi, Dániel Erős, György Mészáros, Ferenc Hollósy, Doris Hafenbradl, Sabine Obert, Bert Klebl, György Kéri, László Őrfi IF(2003): 2.333 (2004)
2.	Drug Discovery in the Kinase Inhibitory Field using the Nested Chemical Library^TM technology ASSAY and Drug Development Technologies, Oct 2005, Vol. 3, No. 5: 543-551 György Kéri^, Zsolt Székelyhidi, Péter Bánhegyi, Zoltán Varga, Bálint-Hegymegi Barakonyi, Csaba Szántai-Kis, Doris Hafenbradl, Bert Klebl, Gerhard Muller, Axel Ullrich, Dániel Erős, Zoltán Horváth, Zoltán Greff, Jenő Marosfalvi, János Pató, István Szabadkai, Ildikó Szilágyi, Zsolt Szegedi, István Varga, Frigyes Wáczek, László Őrfi IF(2003): 1.90*
3.	Antiproliferative Efficacy of a Focused Library of Tyrosine-Kinase Inhibitors Pancreatology, 2003, 3, 209-269 E.Z. Szabó, R. Schwab, G. Bökönyi, F. Hollósy, F. Wáczek, P. Bánhegyi, B. Hegymegi-Barakonyi, B. Németh, E. Várkondi, E. Schafer, S. Radinovic, T. Gyökeres, J. Hamvas, L. Őrfi, M. Idei, G. Kéri. and Á. Pap IF(2002): 1.011
4.	Antiproliferative efficacy of a focus library of tyrosine-kinase inhibitors Zeitschrift für Gastroenterologie, 2003, XLII, 459 Szabó E.Z., Schwab R., Bökönyi G., Hollósy F., Wáczek F., Bánhegyi P., Hegymegi-Barakonyi, B. Németh BB. Várkondi E., Schafer E., Radinovic S., Gyökeres T., Hamvas J., Őrfi L., Idei M., Kéri G. Á. Pap IF(2002): 0.837
5.	Testing and characterising focused tyrosine kinase inhibitory libraryes Biopolymers, 2003, 71 (Meeting Abstract) Bokonyi, G Schafer, E Varkondi, E Szabo, EZ Radinovic, S Waczek, F Szekelyhidi, Z Banhegyi, PG Hegymegi-Barakonyi, B Hollosy, F Orfi, L Schwab, RE Keri, G
6.	Inhibitors of a mycobacterial protein kinase target and their conversion into novel drug candidates for Mycobacterium tuberculosis infected patients FEBS Journal Vol. 272, Issue s1, Page 520, July 2005 L. Õrfi, A. Koul, D. Hafenbradl, B. Klebl, E. Hoppe, A. Missio, G. Müller, A. Ullrich, J. Pató, F. Wáczek, P. Markó, P. Bánhegyi, Z. Greff and G. Kéri
7.	Prediction oriented QSAR modelling of EGFR inhibition. Current Medicinal Chemistry, 2006, 13(3), 277-287 Szantai-Kis, C.; Kovesdi, I.; Eros, D.; Banhegyi, P.; Ullrich, A.; Keri, G.; Orfi, L.
8.	Drug Discovery in the Kinase Inhibitory Field Using the Nested Chemical Library Technology. Assay and Drug Development Technologies, 2005, 3(5), 543-551 Keri, Gyoergy; Szekelyhidi, Zsolt; Banhegyi, Peter; Varga, Zoltan; Hegymegi-Barakonyi, Balint; Szantai-Kis, Csaba; Hafenbradl, Doris; Klebl, Bert; Muller, Gerhard; Ullrich, Axel; Eroes, Daniel; Horvath, Zoltan; Greff, Zoltan; Marosfalvi, Jenoe; Pato, Janos; Szabadkai, Istvan; Szilagyi, Ildiko; Szegedi, Zsolt; Varga, Istvan; Waczek, Frigyes, Oerfi, Laszlo.

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